Re: Ivermectin research at the Doherty institute, Australia

by Red Lily Thu Oct 07, 2021 7:56 pm

A year after the country’s first Covid-19 cluster, with 5 cases, was reported in Agra district, the Uttar Pradesh government has claimed that it was the first state to have introduced a large-scale “prophylactic and therapeutic” use of Ivermectin and added that the drug helped the state to maintain a lower fatality and positivity rate as compared to other states.

Citing the results from Agra in the month of May and June last year, following which the use of Ivermectin, a medicine to treat parasitic ailments, along with Doxycycline was introduced as a protocol across the state for both prophylactic as well as treatment purposes, the state Health Department said it would conduct a controlled study once the second wave of the pandemic subsides.

The state Health Department introduced Ivermectin as prophylaxis for close contacts of Covid patients, health workers as well as for the treatment of the patients themselves through a government order on August 6, 2020, after a committee headed by the Director General, Medical and Health Services, gave it the go ahead.

“Uttar Pradesh was the first state in the country to introduce large-scale prophylactic and therapeutic use of Ivermectin. In May-June 2020, a team at Agra, led by Dr Anshul Pareek, administered Ivermectin to all RRT team members in the district on an experimental basis. It was observed that none of them developed Covid-19 despite being in daily contact with patients who had tested positive for the virus,” Uttar Pradesh State Surveillance Officer Vikssendu Agrawal said.

https://www.msn.com/en-in/news/other/uttar-pradesh-government-says-early-use-of-ivermectin-helped-to-keep-positivity-deaths-low/ar-BB1gDp5U

by Sprintcyclist Thu Oct 07, 2021 10:59 pm

That's good news RedLily

A year after the country’s first Covid-19 cluster, with 5 cases, was reported in Agra district, the Uttar Pradesh government has claimed that it was the first state to have introduced a large-scale “prophylactic and therapeutic” use of Ivermectin and added that the drug helped the state to maintain a lower fatality and positivity rate as compared to other states.

Citing the results from Agra in the month of May and June last year, following which the use of Ivermectin, a medicine to treat parasitic ailments, along with Doxycycline was introduced as a protocol across the state for both prophylactic as well as treatment purposes, the state Health Department said it would conduct a controlled study once the second wave of the pandemic subsides.

The state Health Department introduced Ivermectin as prophylaxis for close contacts of Covid patients, health workers as well as for the treatment of the patients themselves through a government order on August 6, 2020, after a committee headed by the Director General, Medical and Health Services, gave it the go ahead.

“Uttar Pradesh was the first state in the country to introduce large-scale prophylactic and therapeutic use of Ivermectin. In May-June 2020, a team at Agra, led by Dr Anshul Pareek, administered Ivermectin to all RRT team members in the district on an experimental basis. It was observed that none of them developed Covid-19 despite being in daily contact with patients who had tested positive for the virus,” Uttar Pradesh State Surveillance Officer Vikssendu Agrawal said.

He added that based on the findings from Agra, the state government sanctioned the use of Ivermectin as a prophylactic for all the contacts of Covid patients and later cleared the administration of therapeutic doses for the treatment of such patients.

Claiming that timely introduction of Ivermectin since the first wave has helped the state maintain a relatively low positivity rate despite its high population density, he said, “Despite being the state with the largest population base and a high population density, we have maintained a relatively low positivity rate and cases per million of population”.

He said that apart from aggressive contact tracing and surveillance, the lower positivity and fatality rates may be attributed to the large-scale use of Ivermectin use in the state, adding that the drug has recently been introduced in the National Protocol for Covid treatment and management. “Once the second wave subsides, we would conduct our own study as there has been an emerging body of evidence to substantiate our timely use of Ivermectin from the first wave itself,” Vikasendu told The Indian Express.

Agra District Magistrate Prabhu N Singh also attributed the state’s relative success in keeping the Covid numbers down to the timely nod to the use of Ivermectin as a prophylactic. He added that government doctor Anshul Pareek had approached him last year citing use of the medicine abroad.

“We reported the first Covid-19 cluster in the country after five members of a family, who had returned from Italy, tested positive. Soon, the virus spread, with a large number of police personnel getting affected. Doctor Pareek approached me with a request to introduce Ivermectin on an experimental basis. I was told there are no risks involved with the use of the drug,” Singh told The Indian Express.

https://indianexpress.com/article/cities/lucknow/uttar-pradesh-government-says-ivermectin-helped-to-keep-deaths-low-7311786/

by vege57 Thu Oct 07, 2021 11:32 pm

Red Lily wrote:A year after the country’s first Covid-19 cluster, with 5 cases, was reported in Agra district, the Uttar Pradesh government has claimed that it was the first state to have introduced a large-scale “prophylactic and therapeutic” use of Ivermectin and added that the drug helped the state to maintain a lower fatality and positivity rate as compared to other states.

Citing the results from Agra in the month of May and June last year, following which the use of Ivermectin, a medicine to treat parasitic ailments, along with Doxycycline was introduced as a protocol across the state for both prophylactic as well as treatment purposes, the state Health Department said it would conduct a controlled study once the second wave of the pandemic subsides.

The state Health Department introduced Ivermectin as prophylaxis for close contacts of Covid patients, health workers as well as for the treatment of the patients themselves through a government order on August 6, 2020, after a committee headed by the Director General, Medical and Health Services, gave it the go ahead.

“Uttar Pradesh was the first state in the country to introduce large-scale prophylactic and therapeutic use of Ivermectin. In May-June 2020, a team at Agra, led by Dr Anshul Pareek, administered Ivermectin to all RRT team members in the district on an experimental basis. It was observed that none of them developed Covid-19 despite being in daily contact with patients who had tested positive for the virus,” Uttar Pradesh State Surveillance Officer Vikssendu Agrawal said.

https://www.msn.com/en-in/news/other/uttar-pradesh-government-says-early-use-of-ivermectin-helped-to-keep-positivity-deaths-low/ar-BB1gDp5U

"" following which the use of Ivermectin, a medicine to treat parasitic ailments,""

Its my view that any benefit from ivermectin in third world countries is because it reduces their parasitic burden and by doing so allows their bodies to put more resources into fighting the virus

Any animal infested with parasites, either internal or external become very susceptible to other diseases

by vege57 Thu Oct 07, 2021 11:44 pm

It noted that laboratory studies found ivermectin could block replication of SARS-CoV-2 in a test tube, but at much higher ivermectin concentrations than those achieved with the currently authorised doses.

“Results from clinical studies were varied, with some studies showing no benefit and others reporting a potential benefit,” it said.

“Most studies EMA reviewed were small and had additional limitations, including different dosing regimens and use of concomitant medications. EMA therefore concluded that the currently available evidence is not sufficient to support the use of ivermectin in Covid-19 outside clinical trials.”

Also in March, The Journal‘s science factchecker Anthony King provided an overview of some of the evidence to date at that juncture. Since then, further data and analysis has emerged.

Last month, a Cochrane review of 14 studies with a combined 1,678 participants identified the ‘unknowns’ around the use of ivermectin and Covid, including:

if it leads to more or fewer deaths 28 days after treatment;
if it worsens or improves patients’ condition, assessed by need for ventilation, 28 days after treatment;
if it increases or reduces negative Covid-19 tests.
Cochrane is a not-for-profit independent network of researchers, health professionals and patients that gathers and summarises the best evidence from research to help people make informed choices about treatment.

Its authors said their confidence in the evidence was “very low” because they could only include 14 studies with few participants and few events such as deaths or need for ventilation. The methods also differed between studies and they did not report certain factors such as quality of life.

“Based on the current very low- to low-certainty evidence, we are uncertain about the efficacy and safety of ivermectin used to treat or prevent Covid-19,” they said.

“The completed studies are small and few are considered high quality. Several studies are under way that may produce clearer answers in review updates. Overall, the reliable evidence available does not support the use ivermectin for treatment or prevention of Covid-19 outside of well-designed randomised trials.”

https://www.thejournal.ie/factcheck-ivermectin-5526152-Aug2021/

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