STUDY: Ivermectin linked to “large reductions” in covid deaths

Crusader wrote:My best friend, his mother, aunt, and cousin all got covid within the past 2 weeks.  My friend didn't need medical attention, but the others got ivermectin and are doing well.  His aunt was hit worst, but she is about to get out of the hospital.

vege57 wrote:

Crusader wrote:My best friend, his mother, aunt, and cousin all got covid within the past 2 weeks.  My friend didn't need medical attention, but the others got ivermectin and are doing well.  His aunt was hit worst, but she is about to get out of the hospital.

And that is what it is, how many of them were drinking coke ?. I've heard that covid doesn't like the bubbles lol

Elizabeth Theus wrote:

Sprintcyclist wrote:

...........   Ivermectin has been shown to inhibit the replication of SARS-CoV-2 in cell cultures.13 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.14,15 Even though ivermectin appears to accumulate in the lung tissue, predicted systemic plasma and lung tissue concentrations are much lower than 2 µM, the half-maximal inhibitory concentration (IC50) against SARS-CoV-2 in vitro.16-19 Subcutaneous administration of ivermectin 400 µg/kg had no effect on SARS-CoV-2 viral loads in hamsters. However, there was a reduction in olfactory deficit (measured using a food-finding test) and a reduction in the interleukin (IL)-6:IL-10 ratio in lung tissues.20

Since the last revision of this section of the Guidelines, the results of several randomized trials and retrospective cohort studies of ivermectin use in patients with COVID-19 have been published in peer-reviewed journals or have been made available as manuscripts ahead of peer review. Some clinical studies showed no benefits or worsening of disease after ivermectin use,21-24 whereas others reported shorter time to resolution of disease manifestations that were attributed to COVID-19,25-27 greater reduction in inflammatory marker levels,26 shorter time to viral clearance,21 or lower mortality rates in patients who received ivermectin than in patients who received comparator drugs or placebo.21,27

However, most of these studies had incomplete information and significant methodological limitations, which make it difficult to exclude common causes of bias. These limitations include:       ...................

https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ivermectin/

It is not recommended.
That is what I make of it.

You believe info from a government site?   ;o))

.............. All-cause mortality
Meta-analysis of 15 trials, assessing 2438 participants, found that ivermectin reduced the risk of death by an average of 62% (95% CI 27%–81%) compared with no ivermectin treatment [average RR (aRR) 0.38, 95% CI 0.19 to 0.73; I2 = 49%]; risk of death 2.3% versus 7.8% among hospitalized patients in this analysis, respectively (SoF Table 2 and Figure 3). ...............

vege57 wrote:I just wonder where this fascination with Ivermectin started , how did it come onto the scene, ?

Because it is used to kill animals not viruses

Elizabeth Theus wrote:Ivermectin is NOT used to kill animals!

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Ivermectin
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Ivermectin
Generic name: ivermectin (oral) (EYE ver MEK tin)
Brand name: Stromectol
Drug class: Anthelmintics


Medically reviewed by Philip Thornton, DipPharm. Last updated on June 7, 2021.

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Update: Can Ivermectin be used to treat COVID-19?
What is ivermectin?
Ivermectin is an anti-parasite medication.

Ivermectin is used to treat infections in the body that are caused by certain parasites.

Ivermectin is currently being investigated as a treatment for coronavirus SARS-CoV-2, which is the virus that causes COVID-19. The FDA has not approved ivermectin for use in treating or preventing COVID-19 in humans. The World Health Organization (WHO) recommend not to use ivermectin in patients with COVID-19, except in clinical trials.

Click for further information on using ivermectin to treat COVID-19 and other prevention and investigational treatments.