Covid Thoughts
+5
Sprintcyclist
RV
Calypso Jones
jirqoadai
HawkTheSlayer
9 posters
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Re: Covid Thoughts
Welcome to Virginia
New governor Youngkin
We let a Skunk in.
New governor Youngkin
We let a Skunk in.
Calypso Jones- Posts : 28702
Points : 38722
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Join date : 2021-02-08
Age : 24
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Re: Covid Thoughts
Welcome to Virginia
Mother of Presidents
NOT the Mf'in current resident.
Mother of Presidents
NOT the Mf'in current resident.
Calypso Jones- Posts : 28702
Points : 38722
Reputation : 571
Join date : 2021-02-08
Age : 24
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Re: Covid Thoughts
and while driving north from Ashville:
Welcome to Virginia.
Our Peanuts are bigger,
Our govenors a .........
Welcome to Virginia.
Our Peanuts are bigger,
Our govenors a .........
jirqoadai- Posts : 8062
Points : 10045
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Join date : 2021-03-02
Location : hillary still hasnt been shot for treason
HawkTheSlayer likes this post
Re: Covid Thoughts
Found this.
https://pubmed.ncbi.nlm.nih.gov/20305665/
Abstract
Monoclonal antibodies (mAbs) are now established as targeted therapies for malignancies, transplant rejection, autoimmune and infectious diseases, as well as a range of new indications. However, administration of mAbs carries the risk of immune reactions such as acute anaphylaxis, serum sickness and the generation of antibodies. In addition, there are numerous adverse effects of mAbs that are related to their specific targets, including infections and cancer, autoimmune disease, and organ-specific adverse events such as cardiotoxicity. In March 2006, a life-threatening cytokine release syndrome occurred during a first-in-human study with TGN1412 (a CD28-specific superagonist mAb), resulting in a range of recommendations to improve the safety of initial human clinical studies with mAbs. Here, we review some of the adverse effects encountered with mAb therapies, and discuss advances in preclinical testing and antibody technology aimed at minimizing the risk of these events.
Similar articles
Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells.
Eastwood D, Findlay L, Poole S, Bird C, Wadhwa M, Moore M, Burns C, Thorpe R, Stebbings R.
Br J Pharmacol. 2010 Oct;161(3):512-26. doi: 10.1111/j.1476-5381.2010.00922.x.
PMID: 20880392 Free PMC article.
Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release.
Eastwood D, Bird C, Dilger P, Hockley J, Findlay L, Poole S, Thorpe SJ, Wadhwa M, Thorpe R, Stebbings R.
Br J Clin Pharmacol. 2013 Aug;76(2):299-315. doi: 10.1111/bcp.12165.
PMID: 23701319 Free PMC article.
"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.
Stebbings R, Findlay L, Edwards C, Eastwood D, Bird C, North D, Mistry Y, Dilger P, Liefooghe E, Cludts I, Fox B, Tarrant G, Robinson J, Meager T, Dolman C, Thorpe SJ, Bristow A, Wadhwa M, Thorpe R, Poole S.
J Immunol. 2007 Sep 1;179(5):3325-31. doi: 10.4049/jimmunol.179.5.3325.
PMID: 17709549
Giving monoclonal antibodies to healthy volunteers in phase 1 trials: is it safe?
Tranter E, Peters G, Boyce M, Warrington S.
Br J Clin Pharmacol. 2013 Aug;76(2):164-72. doi: 10.1111/bcp.12096.
PMID: 23438102 Free PMC article. Review.
After TGN1412: recent developments in cytokine release assays.
Stebbings R, Eastwood D, Poole S, Thorpe R.
J Immunotoxicol. 2013 Jan-Mar;10(1):75-82. doi: 10.3109/1547691X.2012.711783. Epub 2012 Sep 11.
PMID: 22967038 Free PMC article.
See all similar articles
Cited by 245 articles
The prospect of immunotherapy combined with chemotherapy in patients with advanced non-small cell lung cancer: a narrative review.
Ning X, Yu Y, Shao S, Deng R, Yu J, Wang X, She X, Huang D, Shen X, Duan W, Duan J, Zhang H.
Ann Transl Med. 2021 Nov;9(22):1703. doi: 10.21037/atm-21-4878.
PMID: 34988212 Free PMC article. Review.
Iron oxide nanoparticle targeted chemo-immunotherapy for triple negative breast cancer.
Mu QG, Lin G, Jeon M, Wang H, Chang FC, Revia RA, Yu J, Zhang M.
Mater Today (Kidlington). 2021 Nov;50:149-169. doi: 10.1016/j.mattod.2021.08.002. Epub 2021 Sep 7.
PMID: 34987308
Modifications of IL-6 by Hypochlorous Acids: Effects on Receptor Binding.
Robins LI, Keim EK, Robins DB, Edgar JS, Meschke JS, Gafken PR, Williams JF.
ACS Omega. 2021 Dec 14;6(51):35593-35599. doi: 10.1021/acsomega.1c05297. eCollection 2021 Dec 28.
PMID: 34984290 Free PMC article.
Potential Therapeutic Targets for Combination Antibody Therapy against Pseudomonas aeruginosa Infections.
Proctor LL, Ward WL, Roggy CS, Koontz AG, Clark KM, Quinn AP, Schroeder M, Brooks AE, Small JM, Towne FD, Brooks BD.
Antibiotics (Basel). 2021 Dec 14;10(12):1530. doi: 10.3390/antibiotics10121530.
PMID: 34943742 Free PMC article. Review.
Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases.
Tang XD, Ji TT, Dong JR, Feng H, Chen FQ, Chen X, Zhao HY, Chen DK, Ma WT.
Int J Mol Sci. 2021 Nov 30;22(23):13009. doi: 10.3390/ijms222313009.
https://pubmed.ncbi.nlm.nih.gov/20305665/
Abstract
Monoclonal antibodies (mAbs) are now established as targeted therapies for malignancies, transplant rejection, autoimmune and infectious diseases, as well as a range of new indications. However, administration of mAbs carries the risk of immune reactions such as acute anaphylaxis, serum sickness and the generation of antibodies. In addition, there are numerous adverse effects of mAbs that are related to their specific targets, including infections and cancer, autoimmune disease, and organ-specific adverse events such as cardiotoxicity. In March 2006, a life-threatening cytokine release syndrome occurred during a first-in-human study with TGN1412 (a CD28-specific superagonist mAb), resulting in a range of recommendations to improve the safety of initial human clinical studies with mAbs. Here, we review some of the adverse effects encountered with mAb therapies, and discuss advances in preclinical testing and antibody technology aimed at minimizing the risk of these events.
Similar articles
Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T-cells.
Eastwood D, Findlay L, Poole S, Bird C, Wadhwa M, Moore M, Burns C, Thorpe R, Stebbings R.
Br J Pharmacol. 2010 Oct;161(3):512-26. doi: 10.1111/j.1476-5381.2010.00922.x.
PMID: 20880392 Free PMC article.
Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release.
Eastwood D, Bird C, Dilger P, Hockley J, Findlay L, Poole S, Thorpe SJ, Wadhwa M, Thorpe R, Stebbings R.
Br J Clin Pharmacol. 2013 Aug;76(2):299-315. doi: 10.1111/bcp.12165.
PMID: 23701319 Free PMC article.
"Cytokine storm" in the phase I trial of monoclonal antibody TGN1412: better understanding the causes to improve preclinical testing of immunotherapeutics.
Stebbings R, Findlay L, Edwards C, Eastwood D, Bird C, North D, Mistry Y, Dilger P, Liefooghe E, Cludts I, Fox B, Tarrant G, Robinson J, Meager T, Dolman C, Thorpe SJ, Bristow A, Wadhwa M, Thorpe R, Poole S.
J Immunol. 2007 Sep 1;179(5):3325-31. doi: 10.4049/jimmunol.179.5.3325.
PMID: 17709549
Giving monoclonal antibodies to healthy volunteers in phase 1 trials: is it safe?
Tranter E, Peters G, Boyce M, Warrington S.
Br J Clin Pharmacol. 2013 Aug;76(2):164-72. doi: 10.1111/bcp.12096.
PMID: 23438102 Free PMC article. Review.
After TGN1412: recent developments in cytokine release assays.
Stebbings R, Eastwood D, Poole S, Thorpe R.
J Immunotoxicol. 2013 Jan-Mar;10(1):75-82. doi: 10.3109/1547691X.2012.711783. Epub 2012 Sep 11.
PMID: 22967038 Free PMC article.
See all similar articles
Cited by 245 articles
The prospect of immunotherapy combined with chemotherapy in patients with advanced non-small cell lung cancer: a narrative review.
Ning X, Yu Y, Shao S, Deng R, Yu J, Wang X, She X, Huang D, Shen X, Duan W, Duan J, Zhang H.
Ann Transl Med. 2021 Nov;9(22):1703. doi: 10.21037/atm-21-4878.
PMID: 34988212 Free PMC article. Review.
Iron oxide nanoparticle targeted chemo-immunotherapy for triple negative breast cancer.
Mu QG, Lin G, Jeon M, Wang H, Chang FC, Revia RA, Yu J, Zhang M.
Mater Today (Kidlington). 2021 Nov;50:149-169. doi: 10.1016/j.mattod.2021.08.002. Epub 2021 Sep 7.
PMID: 34987308
Modifications of IL-6 by Hypochlorous Acids: Effects on Receptor Binding.
Robins LI, Keim EK, Robins DB, Edgar JS, Meschke JS, Gafken PR, Williams JF.
ACS Omega. 2021 Dec 14;6(51):35593-35599. doi: 10.1021/acsomega.1c05297. eCollection 2021 Dec 28.
PMID: 34984290 Free PMC article.
Potential Therapeutic Targets for Combination Antibody Therapy against Pseudomonas aeruginosa Infections.
Proctor LL, Ward WL, Roggy CS, Koontz AG, Clark KM, Quinn AP, Schroeder M, Brooks AE, Small JM, Towne FD, Brooks BD.
Antibiotics (Basel). 2021 Dec 14;10(12):1530. doi: 10.3390/antibiotics10121530.
PMID: 34943742 Free PMC article. Review.
Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases.
Tang XD, Ji TT, Dong JR, Feng H, Chen FQ, Chen X, Zhao HY, Chen DK, Ma WT.
Int J Mol Sci. 2021 Nov 30;22(23):13009. doi: 10.3390/ijms222313009.
Calypso Jones- Posts : 28702
Points : 38722
Reputation : 571
Join date : 2021-02-08
Age : 24
Re: Covid Thoughts
I'll just stick with PBR and aspirin.
_________________
Evil is da Devil minus da D.
HawkTheSlayer- Posts : 15720
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Calypso Jones likes this post
Re: Covid Thoughts
Dr. Malone has first hand experience with the Clot Shots. The second one nearly killed him.
https://rwmalonemd.substack.com/p/how-bad-is-my-batch
They know what they're doing to us and to the world. This is intentional. To the vaxxed and unvaxxed. If covid don't get you, we'll get you with the clot shot. We are the guinea pigs, all of us. Vaxxed and u vaxxed, and it matters not if we die. They don't give a fig. I'm not gonna forget this.
https://rwmalonemd.substack.com/p/how-bad-is-my-batch
They know what they're doing to us and to the world. This is intentional. To the vaxxed and unvaxxed. If covid don't get you, we'll get you with the clot shot. We are the guinea pigs, all of us. Vaxxed and u vaxxed, and it matters not if we die. They don't give a fig. I'm not gonna forget this.
Last edited by Calypso Jones on Sat Jan 15, 2022 12:29 am; edited 1 time in total
Calypso Jones- Posts : 28702
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Re: Covid Thoughts
They might not have gotten you this time, but theyll get you later on.
https://www.howbadismybatch.com/
https://www.howbadismybatch.com/
Calypso Jones- Posts : 28702
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Re: Covid Thoughts
https://childrenshealthdefense.org/defender/admit-failure-pandemic-israel-ministry-of-health/?utm_source=salsa&eType=EmailBlastContent&eId=0e833e6f-41d4-4a9c-a3aa-386bf425dd10
Time to Admit Failure,’ Leading Immunologist Tells Israel’s Ministry of Health
Time to Admit Failure,’ Leading Immunologist Tells Israel’s Ministry of Health
_________________
Evil is da Devil minus da D.
HawkTheSlayer- Posts : 15720
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Red Lily- Posts : 12362
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Re: Covid Thoughts
Red Lily wrote:
Mine don't , but them I'm rather exceptional lol
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